1. Eine spektro-kolorimetrische Methode zur Bestimmung der relativen Sättigung von Blutpigmenten mit Sauerstoff wird beschrieben. 2. Die Dissoziationskurve. Exkurs Die Pufferung von menschlichem Blut Der pH-Wert des Bluts eines das fu ̈r den Sauerstofftransport im Blut verantwortlich ist (siehe Exkurs ). Sauerstoffaufnahme Sauerstofftransport im Blut Hämoglobin, Das Sauerstofftransportprotein des Blutes Der Sauerstoffpartialdruck.
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Sauerstofftransport : German » English | PONS
This results in an increased oxygen-binding affinity of isolated hemoglobin and, associated therewith, a reduced oxygen release capacity of such compositions. Development work on derivatized hemoglobin molecules was therefore primarily directed at improving the oxygen transmission properties, and circumvent the rule nephrotoxi symptoms.
The crosslinking of hemoglobin by means of bi- or polyfunctional cross-linking agent can be performed selectively sauerstofftransport im blut non-selectively.
In one form of sauerstofftransport im blut selective cross-linking two protein chains of hemoglobin whereby the natural sauerstofftransport im blut form of the isolated hemoglobin molecule is stabilized intramolecularly joined together. By selecting a suitable Ver netzungsmittels the oxygen affinity of hemoglobin can be further adjusted so that cross-linked hemoglobin can bind oxygen reversibly under physiological conditions.
Examples of such crosslinking agents are pyridoxal phosphate and diaspirin and derivatives thereof. A method for crosslinking of hemoglobin, for example, in Benesch Meth.
Hypoxämie – wenig Sauerstoff im Blut
USA, 84und in Rogers et al. USA, 84and Rogers et al. Acta,beschrieben.
Acta,described. Sauerstofftransport im blut one non-selective crosslinking intermolecularly crosslinked polymeric HBOC products are formed. Appropriate crosslinking agents and methods of use thereof, for example, in DE 07EP A-0 and Hai et al.
Biotech, 22 sauerstofftransport im blutbeschrieben. Biotech, 22 3described. An overview of various hemoglobin derivatives and the costs associated with the clinical use problems enter the publica fentlichungen by Gould et al.
Known hemoglobin conjugates comprising in Xue and Wong Meth. The latter discloses methods by which hemoglobin is bound to hydroxyethyl starch, hydroxyethyl starch sauerstofftransport im blut first riodat with Natriumpe is implemented.
Hypoxämie – wenig Sauerstoff im Blut
About to emerge dialdehydes is bound to the globin hemo. In contrast, DE 26 16 describes the sauerstofftransport im blut of hemoglobin to hydroxyethyl starch by a process in which firstly a crosslinking agent z.
Bromcy on is bound to hydroxyethyl starch and subsequently hemoglobin is linked to the intermediate product. Oxy-hemoglobin oxidizes rapidly to methemoglobin Fe-IIIwhich has too high a sour material binding affinity to be useful as oxygen transport agents.
It was in all processes, a mixture of co-polymer whose constituent parts had different biological activities. The reaction product, or the composition of the mixture was previously only roughly characterized.
The previously HBOC products tested showed additional vascular side effects, which according to the latest sauerstofftransport im blut trials on low molecular weight, ie substantially tetrameric HBOC forms are due see.
The high binding affinity of the hemoglobin for the embroidery oxide NO, also sauerstofftransport im blut as endothelial-derived relaxing factor, EDRF causes the freely available amount of NO is drastically redu sheet in the sem tissue after application of HBOC derivatives.
As a result, the local reduction of the NO concentration, a systemic vasoconstriction leading to hypertension.
Thus hemoglobin in the lungs is cooperatively defined Oxyge and S nitrosiliert. The Sauerstofftransport im blut group is transmitted during the arte rio-venous transition to other proteins as gain by a NO-related, vasodilating activity.